#WINNONLIN PHARMACOKINETIC SOFTWARE FULL#
The full results of the comparison and the model files in SAAM II and PCNonlin/WinNonlin formats are available from the authors. Additionally, there were differences when multiple data sets were fitted, indicating the importance of different fitting procedures for interpreting multiple kinetic data sets. Each specific drug example saved as Excel file that can be used as template for your own data. Emphasis on application to human clinical PK data.
#WINNONLIN PHARMACOKINETIC SOFTWARE SOFTWARE#
User friendly PK and graphical software with built in Physiologically Based Pharmacokinetic, Deconvolution, Non-compartment PK and much more. However, due to differences in the optimization procedure, parameter standard errors showed considerable differences. Freely distributed Java based PK software package. In general, there was good agreement (<1% difference) between SAAM II and PCNonlin in terms of parameter estimates and model predictions. Observed differences, mainly in parameter standard errors, can be accounted for in terms of different optimization algorithms, convergence criteria, and individual capabilities. Parameter estimates, their precision (standard errors), and model predictions were compared a difference of 1% or less was considered “agreement”. The total number of attempted comparisons between SAAM II and PCNonlin was 161, of which 142 executed without problems. We compared 88 different models, many of them in different configurations, e.g., different weighting schemes or different parameter limits. Maximum number of compartments, data sets, and parameters were 9, 5, and 10, respectively. Models investigated included one- and multicompart-ment models with nonlinearities, multiple inputs and samples, multiple simultaneous experiments, and linear equations. Models were initially executed in PCNonlin or WinNonlin and automated comparisons with SAAM II made using Microsoft Test. For each model, both software packages were presented with identical implementations. The NCA, PK/PD modeling tools, and statistical analysis capabilities in WinNonlin are used to support many different types of studies at Everest. Over 6,000 researchers at 1,500 global biopharmaceutical companies, academic institutes and regulatory agencies rely on WinNonlin for their biosimulation studies. This paper presents a detailed comparison of the kinetic analysis software packages SAAM II and PCNonlin/WinNonlin, based on benchmark modeling problems reported in “ Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications” (Gab-rielsson and Weiner, 1994) and seven additional models. Everest uses Phoenix WinNonlin 8.1 to conduct pharmacokinetic (PK) and pharmacodynamic (PD) analysis, modelling and simulation, and non-compartmental analysis (NCA). Phoenix WinNonlin is the trusted industry standard biosimulation software tool for pharmacokinetic and pharmacodynamic (PK/PD) modeling, non-compartmental and compartmental analysis.
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